For us we noticed a change right away and then nothing...I was getting so irritated and didn't know why it wasn't working. But slowly it did work. And it looks so much better to the point people have forgotten about it. She is now off of propanolol but is on timolol because her hemangioma is being stubborn. She has a deep one, under the skin by the way. Good luck and all I can tell you is be patient. If you would like to talk further I'd be glad to talk with you.
Deep hemangioma on left eyebrow towards nose
Started propanolol Feb. 11th, 2010
Off of propanolol aprox. June 2011
Takes 3 doses per day at 1.3ml
2nd Weaning of prop. not a success back on it March 22. Only one dose of 1.3ml now- 19 months old Did Timolol gel for awhile, stopped, & back on - 4 years old. Off of Timolol -doesn't seem to be doing anything. Surgery was a success!!! April 2014